"Translational Research - Bench to Bedside | Bench to CLinical Microbiology"
Biofilms (anti-Koch) or 'sociomicrobiology' has been the core of Dr. Thomas's student-driven translational research since 2000, linking, initially, migrating oral microbiota with ventilator-associated pneumonia (VAP), studied with his design of a closed VEL (Ventilator-Endotrach-Lung) model establishing the lumen of endotrachs as a key reservoir in 1) air way occlusion and 2) lung inoculation in VAP/VAC.
His innovative thinking was unmasked by his concept that biofilms and tumors had at least 8 common features, catalyzing the treatment there that tumors are eukaryotic biofilms with 4-stages.
Secondarily, Dr. Thomas linked parallel pathogenic pathways in oral wound biofilms (periodontal disease) and chronic wounds (skin), integrating the "disruption/reconstructive" strategy in both, unmasking the probiotic or 'therapeutic bacteria' as "restorative microbiology" concept in chronic wounds. Presently, therapeutic bacteria carried in a bioplastic matrix (prebiotics), acting as a biological barrier, is the main focus, recognizing a "Biological Clock" in chronic diseases amplified by a changing human microbiota. These bio-bandaids could be shape-formed to meet a variety of wound environments by 3-D-printing.
Initially, Dr. Thomas focused on oral biofilms and periodontal disease and the use of low-dose doxycycline (LDD) or subtherapeutic doxy (Perio STAT), launched in 1998. Antibiotic resistance, a key component in his "disruption/reconstructive" strategy, has recently driven the "beyond MDR" recognizing the untoward impact of antibiotics in early childhood (the clock) biological.
Dr. Thomas has been involved in multiple FDA interactions/discussions and is an expert in strategizing and implementing clinical trials, including development of IDE and 510 protocols.
He has extensive experience as an 'expert witness' in microbiology and infectious diseases, ranging from food poisoning, "sick building syndrome" to pneumonia and the ICU.
Questions or Comments?
johnthomas070@gmail.com
304 685 5367
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