RESTORATIVE MICROBIOLOGY, “NEUTRACHEMICALS”: PROBIOTICS/PSYCHOBIOTICS

 

• Establish a standardized pre/probiotic strategy based on published research, expanding to complement antibiotic therapy.
• Understand manufactures vary significantly in quality of probiotics and measurement of dose at times of use.
• Probiotics have changed from an adjunctive care to a therapeutic strategy.
• The Metagenomics defines the genetic strength of microbiota a non-structured (organ system) that requires stewardship by Minimal Intervention for optimal effectiveness.
• Probiotics are temporary colonizers that do not establish a recalcitrant biofilms community
• Matching (Microbial Clock) this Rubic’s Cube  is the solution for optimum probiotic efficacy, including the patient Enterotype, 1,2 or 3 ( GUT Signature)
• An ideal Synbiotic (Combinations of selected probiotics) will probably have 3-5 microbes based on biofilm stability and stress maintenance via Diversity and Resilience (D/R). Designer Probiotics or Intelligent Probiotics will self-manage, self-treat and self-monitor infections attributable to biofilms.
• Recognizing the importance of commensal microbes and nonpathogens , Sacchromyces bulardi should be a key component of any probiotic particularly following ABX Rx.
• Generally, synbiotics should use a combination of microbes emphasizing bioburden reduction and immunomodulation;  presently biofilm producing probiotics have highlighted Predatory Probiotics ( Tb) and Tumor homing or detection of altered metabolic states in mutagenesis.( Bifidobacterium)