SMarT Concept : Ecologically Friendly
John G Thomas PhD Professor Emeritus
Intellectual Design integrating disruptive/restorative microbial engineering via Probiotics :
- Intellectual Design for public health care linking1) disruption of microbial bio-burden (both Biofilm and Planktonic phenotypes) followed by 2) Restorative (reconstructive)microbial engineering(Pre-Probiotic/Synbiotic), effectively reestablishing viable , protective 1) normal skin microbiota and 2)tissue regeneration (recognizing that the tissue microbiota is the largest human organ system)
- This Pre-Probiotic /Restorative approach has strong EU/UK history in oral health (dentistry) with growing ,emerging application in multiple ,costly Public Health Diseases, Birth to Death, but never linked in a single concept of Minimal Intervention(MI) recognizing the collateral damage associated with global over use of antibiotics , MDR (23,000 USA deaths) and amplification in under six month of age children chronic diseases , including asthma, allergies, diabetes and obesity.
- The emergence of Pre-Probiotic Therapy has been catalyzed by recent advances in microbiota/mycobiota and metagenomics ( Genetic Strength), unmasking the important of our 4-Quadrant "Microbial Clock" and interaction/signaling of procaryots - eucaryots (bug-bug , bug - host tissue and host tissue – host tissue) via immuno -amplification/up regulation and organism bio-burden reduction below "critical colonization" pathogenicity .
- Although initially focused on chronic wound care/ silver dressings, the "suite platform " approach of silver dressing disruption/ probiotic restorative intervention has potential broad public health care application, including incorporating biomedical sensors , nanotechnology and 'micro 3-D bio printing' directed at 1) prevention as well as 2) curative outcomes.
